(3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

Base Information

Chemical Name:(3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester
CAS No.:254750-63-5
Molecular Formula:C₂₃H₃₅FN₂O₆
Molecular Weight:454.539
Hs Code.:

Synonyms:(3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

Chemical Property:

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Technology Process of (3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

There total 2 articles about (3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161401-79-2,325705-48-4
(3RS,4RS)-3-amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

: 3397-35-1
Z-L-leucine hydroxysuccinimide ester

: 254750-63-5
(3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 2018-66-8
Z-Leu-OH

: 161401-79-2,325705-48-4
3-amino-4-hydroxy-5-fluoropentanoic acid,tert-butyl ester

: 254750-63-5
(3RS,4RS)-3-[(N-benzyloxycarbonyl)leucinyl]amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.bmcl.2003.12.065