(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

Base Information

Chemical Name:(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine
CAS No.:1544006-04-3
Molecular Formula:C₁₃H₂₀F₄N₂
Molecular Weight:280.309
Hs Code.:

Synonyms:(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

Chemical Property:

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Technology Process of (3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

There total 5 articles about (3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₈F₄N₂O

: 1544006-04-3
(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

Reference yield:

: 1400707-08-5
cyclopropyl [(3S,4R)-3-fluoropiperidin-4-yl]carbamic acid tert-butyl ester

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1544006-04-3
(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

Guidance literature:: cyclopropyl [(3S,4R)-3-fluoropiperidin-4-yl]carbamic acid tert-butyl ester; 1-(trifluoromethyl)cyclopropanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

Reference yield:

: 1400707-08-5
cyclopropyl [(3S,4R)-3-fluoropiperidin-4-yl]carbamic acid tert-butyl ester

: 1544006-04-3
(3S,4R)-N-cyclopropyl-3-fluoro-1-[1-(trifluoromethyl-cyclopropylmethyl)]-piperidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;