methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate

Base Information

• Chemical Name: methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate
• CAS No.: 127845-14-1
• Molecular Formula: C₁₈H₁₆O₃
• Molecular Weight: 280.323

Synonyms:methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate

Chemical Property of methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate

Chemical Property:

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Technology Process of methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate

There total 5 articles about methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + trans-(2R*,3S*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid (128080-53-5) → methyl trans-(2R*,3R*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate (127845-14-1)

Guidance literature:

In diethyl ether; at 20 ℃; for 10h;

Reference yield: 65.0%

dimethyl erythro-(1R*,2R*)-1,3-diphenylpropane-1,2-dicarboxylate (20972-45-6,20972-46-7,42336-72-1,42336-73-2) → methyl trans-(2R*,3R*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate (127845-14-1)

Guidance literature:

With PPA; at 98 - 100 ℃; for 0.5h;

Reference yield:

erythro-(1R*,2R*)-1,3-diphenylpropane-1,2-dicarboxylic acid (5653-90-7,42336-74-3,42336-75-4,56908-50-0,56908-51-1) → methyl trans-(2R*,3R*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate (127845-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether / 12 h

2: 65 percent / polyphosphoric acid / 0.5 h / 98 - 100 °C

With PPA; In diethyl ether;

upstream raw materials:

diazomethane

trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid

dimethyl erythro-(1R^*,2R^*)-1,3-diphenylpropane-1,2-dicarboxylate

erythro-(1R^*,2R^*)-1,3-diphenylpropane-1,2-dicarboxylic acid

Downstream raw materials:

(E)-methyl 3-phenyl-4-hydroxyimino-1,2,3,4-tetrahydronaphthalene-2-carboxylate

(Z)-methyl 3-phenyl-4-hydroxyimino-1,2,3,4-tetrahydronaphthalene-2-carboxylate

C₂₀H₁₉NO₄

C₂₀H₁₉NO₄

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