1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester
CAS No.:945490-07-3
Molecular Formula:C₂₂H₂₂N₂O₇
Molecular Weight:426.426
Hs Code.:

Synonyms:1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of 1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

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Technology Process of 1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

There total 10 articles about 1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 84348-41-4
(S)-methyl 4-methylenepyrrolidine-2-carboxylate hydrochloride

: 945490-07-3
1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

Reference yield: 85.0%

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 945490-07-3
1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: 4-methylene-L-proline methyl ester trifluoroacetate; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0333333h;

4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 4.66667h;

Reference yield: 76.1%

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 84348-41-4
(S)-methyl 4-methylenepyrrolidine-2-carboxylate hydrochloride

: 945490-07-3
1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

(S)-methyl 4-methylenepyrrolidine-2-carboxylate hydrochloride; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h; Inert atmosphere;