(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

Base Information

Chemical Name:(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde
CAS No.:945490-08-4
Molecular Formula:C₂₁H₂₀N₂O₆
Molecular Weight:396.4
Hs Code.:

Synonyms:(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

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Chemical Property of (S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

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Technology Process of (S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

There total 13 articles about (S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 260418-16-4
(2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-2-(hydroxymethyl)-4-methylidenepyrrolidine

: 945490-08-4
(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

Guidance literature:: (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-2-(hydroxymethyl)-4-methylidenepyrrolidine; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

Reference yield: 92.0%

: 945490-07-3
1-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-(2S)-4-methylenepyrrolidine-2-carboxylic acid methyl ester

: 945490-08-4
(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 2.5h; Cooling with acetone-dry ice;

Reference yield:

: 121-34-6
3-methoxy-4-hydroxybenzoic acid

: 945490-08-4
(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)-4-methylenepyrrolidine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol / 8 h / 65 °C

2: acetic acid; nitric acid / dichloromethane / 6 h

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: diisobutylaluminium hydride / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

With oxalyl dichloride; nitric acid; diisobutylaluminium hydride; acetic acid; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane;