Methyl 2-oxoindoline-4-carboxylate

Base Information

Chemical Name:Methyl 2-oxoindoline-4-carboxylate
CAS No.:90924-46-2
Molecular Formula:C₁₀H₉NO₃
Molecular Weight:191.186
Hs Code.:2933790090
DSSTox Substance ID:DTXSID30595459
Wikidata:Q72494117
Mol file:90924-46-2.mol

Synonyms:90924-46-2;Methyl 2-oxoindoline-4-carboxylate;METHYL OXINDOLE-4-CARBOXYLATE;Methyl 2-oxindole-4-carboxylate;METHYL 2-OXO-1,3-DIHYDROINDOLE-4-CARBOXYLATE;METHYL 2-OXO-2,3-DIHYDRO-1H-INDOLE-4-CARBOXYLATE;1H-INDOLE-4-CARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-, METHYL ESTER;MFCD08277245;Methyl2-Oxoindoline-4-carboxylate;methylphosphorodichloridate;SCHEMBL5362141;AMY7611;DTXSID30595459;FBKDEECWCACPLH-UHFFFAOYSA-N;Methyl 2-oxo-4-indolinecarboxylate;Methyl-2-oxoindoline-4-carboxylate;AKOS006285004;AC-1216;PB23593;DS-18186;SY030704;DB-057230;CS-0011498;EN300-245973;A843674;Q-102615;2,3-Dihydro-2-oxo-1H-indole-4-carboxylic acid, methyl ester

Suppliers and Price of Methyl 2-oxoindoline-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyloxindole-4-carboxylate
500mg
$ 265.00

SynQuest Laboratories
Methyl 2-oxindole-4-carboxylate
1 g
$ 345.00

Labseeker
METHYLOXINDOLE-4-CARBOXYLATE 98
50g
$ 1036.00

Crysdot
Methyl2-oxoindoline-4-carboxylate 97%
5g
$ 430.00

Crysdot
Methyl2-oxoindoline-4-carboxylate 97%
10g
$ 597.00

Chemenu
methyl2-oxo-2,3-dihydro-1H-indole-4-carboxylate 95%+
25g
$ 1078.00

Chemenu
methyl2-oxo-2,3-dihydro-1H-indole-4-carboxylate 95%+
10g
$ 550.00

Chemenu
methyl2-oxo-2,3-dihydro-1H-indole-4-carboxylate 95%+
5g
$ 396.00

Apolloscientific
Methyloxindole-4-carboxylate 95%
1g
$ 235.00

Apolloscientific
Methyloxindole-4-carboxylate 95%
250mg
$ 115.00

Total 50 raw suppliers

Chemical Property of Methyl 2-oxoindoline-4-carboxylate

Chemical Property:

Vapor Pressure:1.13E-06mmHg at 25°C
Boiling Point:402°C at 760 mmHg
Flash Point:196.9°C
PSA：55.40000
Density:1.283g/cm³
LogP:1.10580
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.058243149
Heavy Atom Count:14
Complexity:264

Purity/Quality:

99%, ^*data from raw suppliers

Methyloxindole-4-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C2CC(=O)NC2=CC=C1

Technology Process of Methyl 2-oxoindoline-4-carboxylate

There total 8 articles about Methyl 2-oxoindoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.7%

: 93534-73-7
3-Nitro-homophthalsaeure-dimethylester

: 90924-46-2
2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2015.08.060

Reference yield: 39.0%

: 3,3-dibromo-2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid methyl ester

: 90924-46-2
2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: With acetic acid; zinc; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm400138z

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 90924-46-2
2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 5 h / Reflux

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

3: water; methanol / 5 h / 20 °C

4: hydrogenchloride / water

5: thionyl chloride / 4 h / Reflux

6: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; palladium 10% on activated carbon; hydrogen; dibenzoyl peroxide; In methanol; tetrachloromethane; water;
DOI:10.1016/j.bmcl.2015.08.060