2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one

Base Information

• Chemical Name: 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one
• CAS No.: 1431735-60-2
• Molecular Formula: C₂₉H₃₆ClN₅O₂
• Molecular Weight: 522.09
• Mol file: 1431735-60-2.mol

Synonyms:2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one

Chemical Property of 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one

There total 5 articles about 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

N-[3-(piperidin-4-yl)phenyl]-acetamide (387827-25-0) + 2-(3-chloropropyl)-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one (1431735-95-3) → 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one (1431735-60-2)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.5012/bkcs.2013.34.12.3851

Reference yield:

C13H13Cl2N3 (1592030-41-5) → 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one (1431735-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 2 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 100 °C

With sodium hydride; sodium carbonate; acetic acid; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2013.34.12.3851

Reference yield:

C13H14ClN3O (1431736-16-1) → 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one (1431735-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 100 °C

With sodium hydride; sodium carbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2013.34.12.3851

upstream raw materials:

C₁₃H₁₃Cl₂N₃

C₁₃H₁₄ClN₃O

N-[3-(piperidin-4-yl)phenyl]-acetamide

2-(3-chloropropyl)-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one