2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

Base Information

Chemical Name:2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole
CAS No.:103795-35-3
Molecular Formula:C₁₇H₂₁NO₃S
Molecular Weight:319.425
Hs Code.:

Synonyms:2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

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Chemical Property of 2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

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Technology Process of 2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

There total 11 articles about 2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103795-14-8
(1R)-2-O-benzyl-3,4-O-isopropylidene-1-(2-thiazolyl)-D-erythritol

: 103795-35-3
2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

Guidance literature:: With tri-n-butyl-tin hydride; di(1H-imidazol-2-yl)methanethione; Multistep reaction; 1) THF, reflux; 2) toluene, reflux;

Reference yield:

: 103795-12-6
(R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 103795-35-3
2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2) nBu₄NF / 1) CH₂Cl₂, 10 h, room temp.; 2) THF, 2 h

2: 1) thiocarbonyl diimidazole; 2) nBu₃SnH / 1) THF, reflux; 2) toluene, reflux

With tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; di(1H-imidazol-2-yl)methanethione;

Reference yield:

: 103795-10-4
(2R,3R)-1,2-O-Isopropylidene-3-(2-thiazolyl)-1,2,3-propanetriol

: 103795-35-3
2-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH; 2) nBu₄NI / 1) THf, 30 min., room temp.; 2) 3 h

3: 2) nBu₄NF / 1) CH₂Cl₂, 10 h, room temp.; 2) THF, 2 h

4: 1) thiocarbonyl diimidazole; 2) nBu₃SnH / 1) THF, reflux; 2) toluene, reflux

With tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; di(1H-imidazol-2-yl)methanethione;