Technology Process of 2,4,6-Trimethyl-benzenesulfonic acid (2R,3S)-3-benzyloxy-2-hydroxy-4-thiazol-2-yl-butyl ester
There total 10 articles about 2,4,6-Trimethyl-benzenesulfonic acid (2R,3S)-3-benzyloxy-2-hydroxy-4-thiazol-2-yl-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) 50percent NaH, 2.) tetra-n-butylammonium iodide / 1.) reflux, 20 min, 2.) room temp., overnight
2: 94 percent / acetonitrile / 7 h / Heating
3: 70 percent / NaBH4 / methanol / 0.5 h / -10 °C
4: 86 percent / H2O, HgCl2 / acetonitrile / 0.25 h / Ambient temperature
5: CH2Cl2 / 12 h / Ambient temperature
6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h
7: 5 h / Heating
8: Bu3SnH / toluene / 6 h / Heating
9: CF3COOH / H2O / 0 °C
10: pyridine / 12 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid; mercury dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo00264a035
- Guidance literature:
-
Multi-step reaction with 6 steps
1: CH2Cl2 / 12 h / Ambient temperature
2: tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h
3: 5 h / Heating
4: Bu3SnH / toluene / 6 h / Heating
5: CF3COOH / H2O / 0 °C
6: pyridine / 12 h / Ambient temperature
With
pyridine; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo00264a035
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 94 percent / acetonitrile / 7 h / Heating
2: 70 percent / NaBH4 / methanol / 0.5 h / -10 °C
3: 86 percent / H2O, HgCl2 / acetonitrile / 0.25 h / Ambient temperature
4: CH2Cl2 / 12 h / Ambient temperature
5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h
6: 5 h / Heating
7: Bu3SnH / toluene / 6 h / Heating
8: CF3COOH / H2O / 0 °C
9: pyridine / 12 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; tri-n-butyl-tin hydride; trifluoroacetic acid; mercury dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo00264a035
