(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

Base Information

Chemical Name:(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol
CAS No.:110450-60-7
Molecular Formula:C₁₈H₃₄NO₄PS
Molecular Weight:391.512
Hs Code.:

Synonyms:(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

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Chemical Property of (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

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Technology Process of (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

There total 10 articles about (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (3R,5S)-5-[(Diphenylphosphanyl)-methyl]-1-methanesulfonyl-pyrrolidin-3-ol

: 110450-60-7
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

Guidance literature:: With hydrogen; rhodium on alumina; In methanol; at 150 ℃; for 48h; under 114000 Torr;
DOI:10.1246/cl.1986.2061

Reference yield: 96.0%

: 110466-09-6
(3R-trans)-5-<(diphenylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

: 110450-60-7
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

Guidance literature:: With rhodium on alumina; hydrogen; In methanol; at 150 ℃; for 48h; under 114000 Torr;
DOI:10.1248/cpb.42.481

Reference yield:

: 33996-30-4
trans-4-hydroxy-L-proline ethyl ester hydrochloride

: 110450-60-7
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / anh. pyridine / a) 0 deg C, 6 h, b) RT, 15 h

2: 87 percent / LiAlH₄ / tetrahydrofuran / a) 0 deg C, 3 h, b) RT, 3 h

3: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

4: 100 percent / pTsOH monohydrate / CH₂Cl₂ / 3 h / Ambient temperature

5: 67 percent / tetrahydrofuran; dioxane / a) 0 deg C, 6 h, b) RT, 13 h

6: 10percent aq. H₂O₂ / methanol / 1 h / Ambient temperature

7: pTsOH monohydrrate / methanol; H₂O / 1 h / Heating

8: 96 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

With pyridine; lithium aluminium tetrahydride; rhodium on alumina; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1248/cpb.42.481