N-(3-chloro-2-formylphenyl)benzamide

Base Information

• Chemical Name: N-(3-chloro-2-formylphenyl)benzamide
• CAS No.: 51489-13-5
• Molecular Formula: C₁₄H₁₀ClNO₂
• Molecular Weight: 259.692
• Mol file: 51489-13-5.mol

Synonyms:N-(3-chloro-2-formylphenyl)benzamide

Chemical Property of N-(3-chloro-2-formylphenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(3-chloro-2-formylphenyl)benzamide

There total 4 articles about N-(3-chloro-2-formylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-benzaldehyde (89-98-5) + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → N-(3-chloro-2-formylphenyl)benzamide (51489-13-5)

Guidance literature:

With silver hexafluoroantimonate; [Cp·(CoCO)I₂]; sodium pivalate; aniline; In 1,2-dichloro-ethane; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201901267

Reference yield:

Benzohydroxamic acid (495-18-1) → N-(3-chloro-2-formylphenyl)benzamide (51489-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; water / 2,2,2-trifluoroethanol / 12 h / 100 °C / Inert atmosphere; Sealed tube

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; water; In dichloromethane; 2,2,2-trifluoroethanol;

DOI:10.1039/c8cc04904a

Reference yield:

benzoyl chloride (98-88-4) → N-(3-chloro-2-formylphenyl)benzamide (51489-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; potassium carbonate / ethyl acetate; water / 0 - 20 °C

2: dichloromethane / 20 °C

3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; water / 2,2,2-trifluoroethanol / 12 h / 100 °C / Inert atmosphere; Sealed tube

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; hydroxylamine hydrochloride; water; potassium carbonate; In dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate;

DOI:10.1039/c8cc04904a

upstream raw materials:

Benzohydroxamic acid

benzoyl chloride

2-chloro-benzaldehyde

3-phenyl-5H-1,4,2-dioxazol-5-one