PYRROLIDIN-1-YL-ACETIC ACID

Base Information

• Chemical Name: PYRROLIDIN-1-YL-ACETIC ACID
• CAS No.: 37386-15-5
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 2933990090
• Mol file: 37386-15-5.mol

Synonyms:(Pyrrolidino)aceticacid;1-Pyrrolidinylacetic acid;2-(Pyrrolidin-1-yl)acetic acid;N-Pyrrolidinoacetic acid;

Chemical Property of PYRROLIDIN-1-YL-ACETIC ACID

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Melting Point: 184-185 °C
• Refractive Index: 1.499
• Boiling Point: 233.8 oC at 760mmHg
• PKA: 2.47±0.10(Predicted)
• Flash Point: 95.2 oC
• PSA: 40.54000
• Density: 1.153g/cm³
• LogP: 0.10470
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly, Sonicated, Heated), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1-?PyrrolidineaceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-?Pyrrolidineacetic Acid is a useful reactant and reagent in organic reactions. It can be found used in cosmetic products such as wrinkle-?preventive?/ameliorating products.

Technology Process of PYRROLIDIN-1-YL-ACETIC ACID

There total 7 articles about PYRROLIDIN-1-YL-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 2-(pyrrolidin-1-yl)acetate → 2-(pyrrolidin-1-yl)acetic acid (37386-15-5)

Guidance literature:

In water; isopropyl alcohol; at 160 ℃; for 0.333333h; Flow reactor;

DOI:10.1016/j.bmc.2017.03.020

Reference yield: 91.0%

ethyl 2-(pyrrolidin-1-yl) acetate (22041-19-6) → 2-(pyrrolidin-1-yl)acetic acid (37386-15-5)

Guidance literature:

With hydrogenchloride; In water; at 95 ℃; for 16h;

Reference yield: 73.0%

pyrrolidine (123-75-1) + bromoacetic acid (79-08-3) → 2-(pyrrolidin-1-yl)acetic acid (37386-15-5)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 72h; pH=14;

DOI:10.1016/j.bmc.2004.10.004

upstream raw materials:

ethyl 2-(pyrrolidin-1-yl) acetate

pyrrolidine

bromoacetic acid

methyl 2-(pyrrolidin-1-yl)acetate

Downstream raw materials:

dibenzyl pyrrolidinoglycyl-L-prolyl-L-glutamate

benzyl N-[(12R,16S,18S)-8,13-dioxo-16-{[2-(1-pyrrolidinyl)acetyl]amino}-20-oxa-9,14-diazatetracyclo[19.3.1.0²'⁷.0¹⁴'¹⁸]pentacosa-1⁽²⁵⁾,2,4,6,21,23-hexaen-12-yl]carbamate

5-[4-(2H-pyrazol-3-yl)phenoxy]-2-pyrrolidin-1-ylmethyl-1H-benzoimidazole

C₂₇H₃₇N₅O₃Si

Refernces

• 1、 Cole, Kevin P.,Ryan, Sarah J.,Groh, Jennifer McClary,Miller, Richard D.. "Reagent-free continuous thermal tert-butyl ester deprotection". . p. 6209 - 6217. Retrieved 2017/09/30.
• 2、 -. "PROTEIN KINASE INHIBITORS". Page/Page column 40. . Retrieved 2013/04/25.