2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine

Base Information

• Chemical Name: 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine
• CAS No.: 1415353-82-0
• Molecular Formula: C₂₁H₂₄N₂O₃
• Molecular Weight: 352.433
• Mol file: 1415353-82-0.mol

Synonyms:2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine

Chemical Property of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine

There total 3 articles about 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethyl-5-nitroquinoline (1415353-81-9) → 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine (1415353-82-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 1h; Reflux;

DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

2-chloro-3-ethylquinoline (67525-28-4) → 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine (1415353-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 1.33 h / -10 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / Reflux

3: ammonium chloride; iron / water; ethanol / 1 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; iron; sodium carbonate; ammonium chloride; In 1,2-dimethoxyethane; ethanol; water; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

2-chloro-3-ethyl-5-nitroquinoline (1415353-80-8) → 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethylquinolin-5-amine (1415353-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / Reflux

2: ammonium chloride; iron / water; ethanol / 1 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; sodium carbonate; ammonium chloride; In 1,2-dimethoxyethane; ethanol; water; 1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

upstream raw materials:

2-chloro-3-ethylquinoline

2-chloro-3-ethyl-5-nitroquinoline

2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-ethyl-5-nitroquinoline

Downstream raw materials:

2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N,3-triethylquinolin-5-amine