Technology Process of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N,3-triethylquinolin-5-amine
There total 4 articles about 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N,3-triethylquinolin-5-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / 1.33 h / -10 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 4 h / Reflux
3: ammonium chloride; iron / water; ethanol / 1 h / Reflux
4: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 4.5 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water;
2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028
DOI:10.1016/j.bmc.2012.09.028
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonium chloride; iron / water; ethanol / 1 h / Reflux
2: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 4.5 h / 20 °C
With
sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid;
In
tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2012.09.028
DOI:10.1016/j.bmc.2012.09.028