4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine

Base Information

• Chemical Name: 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine
• CAS No.: 935762-22-4
• Molecular Formula: C₂₆H₂₇NO₂
• Molecular Weight: 385.506
• Mol file: 935762-22-4.mol

Synonyms:4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine

Chemical Property of 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine

There total 2 articles about 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

E-trifluoro-methanesulfonic acid (4-benzyl-morpholin-2-ylidene)-phenyl-methyl ester (860013-73-6) → 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine (935762-22-4)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 95 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.02.013

Reference yield:

(4-benzyl-morpholin-2-yl)-phenylmethanone (521969-46-0) → 4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine (935762-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tBuOK; 18-crown-6; H₂O / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: tetrahydrofuran / 20 °C

2.1: 85 percent / Pd(PPh₃)4 / tetrahydrofuran / 1 h / 95 °C

With 18-crown-6 ether; potassium tert-butylate; water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.02.013

Reference yield: 81.0%

4-benzyl-2-[2-(2-methoxy-phenyl)-1-phenyl-ethylidene]-morpholine (935762-22-4) → 2-[2-(2-methoxy-phenyl)-1-phenyl-ethyl]-morpholine

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2007.02.013

upstream raw materials:

E-trifluoro-methanesulfonic acid (4-benzyl-morpholin-2-ylidene)-phenyl-methyl ester

(4-benzyl-morpholin-2-yl)-phenylmethanone