521969-46-0

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 147767-51-9 4-benzyl-2-cyanomorpholine 
• 104-63-2 N-Benzylethanolamine 
• 108-86-1 bromobenzene 

Downstream Products

• 860013-73-6 E-trifluoro-methanesulfonic acid (4-benzyl-morpholin-2-ylidene)-phenyl-methyl ester 
• 800407-77-6 (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol 
• 664361-21-1 4-benzyl-2-(2-phenyl-oxiranyl)-morpholine 
• 800407-86-7 (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(5-fluoro-2-methoxy-phenyl)-1-phenyl-ethanol 
• 800407-79-8 (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-isopropoxy-phenyl)-1-phenyl-ethanol 
• 800407-81-2 (S,R)-1-(4-benzyl-morpholin-2-yl)-1-phenyl-2-(2-trifluorometoxy-phenyl)-ethanol 
• 664361-10-8 (2S)-(4-benzyl-morpholin-2-yl)-phenyl-methanone 
• 935762-23-5 4-benzyl-2-{2-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-phenyl-ethylidene}-morpholine 

Relevant academic research and scientific papers

Synthesis and evaluation of fluorinated analogues of monoamine reuptake inhibitors

The synthesis of two series of fluorinated analogues of monoamines reuptake inhibitors based on tertiary alcohols 2-substituted morpholines scaffold has been achieved through the incorporation of fluorinated substituent into 2-substituted morpholino ketones. Their binding affinities have been measured on different monoamine transporters.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS

Provided are methods and medicaments for treating a learning disability or a Motor Skills Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.

TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH NOREPINEPHRINE REUPTAKE INHIBITORS

Provided are methods and medicaments for treating a Pervasive Developmental Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.

TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION

Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.

ARYL AND HETEROARYL MORPHOLINE DERIVATIVES

Compounds of formula (I) are selective inhibitors of the reuptake of norepinephrine, wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionall

MORPHOLINE DERIVATIVES

Compounds of formula (I), wherein: A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3-C6 cycloalkyl group or a CH2(C3-C6 cycloalkyl) group; R' is H or C1-C4 alkyl; and each R