N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
CAS No.:1609576-08-0
Molecular Formula:C₁₇H₁₂FN₃O₆
Molecular Weight:373.297
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

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Technology Process of N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

There total 6 articles about N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1609575-99-6
N-(4-fluorobenzyl)-2-(benzyloxy)-3-hydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

: 1609576-08-0
N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: N-(4-fluorobenzyl)-2-(benzyloxy)-3-hydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide; With boron trichloride; In dichloromethane; at -78 ℃; for 1h;

With water; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jm500109z

Reference yield:

: 16426-64-5
2-bromo-4-nitrobenzoic acid

: 1609576-08-0
N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide; sodium hydride / mineral oil; toluene / 2.5 h / 75 °C / Inert atmosphere

2.1: thionyl chloride / 16 h / 0 °C / Reflux

3.1: toluene / Reflux; Dean-Stark

4.1: potassium hydroxide / methanol / 20 °C

5.1: toluene / 1 h / Reflux; Dean-Stark

6.1: boron trichloride / dichloromethane / 1 h / -78 °C

6.2: 0.25 h / 0 °C

With thionyl chloride; boron trichloride; sodium hydride; potassium hydroxide; copper(I) bromide; In methanol; dichloromethane; toluene; mineral oil;
DOI:10.1021/jm500109z

Reference yield:

: 186390-71-6
2-(carboxy-5-nitro-phenyl)malonic acid dimethyl ester

: 1609576-08-0
N-(4-fluorobenzyl)-2,3-dihydroxy-6-nitro-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 16 h / 0 °C / Reflux

2.1: toluene / Reflux; Dean-Stark

3.1: potassium hydroxide / methanol / 20 °C

4.1: toluene / 1 h / Reflux; Dean-Stark

5.1: boron trichloride / dichloromethane / 1 h / -78 °C

5.2: 0.25 h / 0 °C

With thionyl chloride; boron trichloride; potassium hydroxide; In methanol; dichloromethane; toluene;
DOI:10.1021/jm500109z