(6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

Base Information

• Chemical Name: (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine
• CAS No.: 1059182-91-0
• Molecular Formula: C₁₅H₁₅F₃N₂O
• Molecular Weight: 296.292
• Mol file: 1059182-91-0.mol

Synonyms:(6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

Chemical Property of (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

There total 2 articles about (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-pyridin-3-ylamine (6628-77-9) + 4-Trifluoromethylphenylacetic acid (32857-62-8) → (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine (1059182-91-0)

Guidance literature:

6-methoxy-pyridin-3-ylamine; 4-Trifluoromethylphenylacetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With borane-THF; In tetrahydrofuran; at 60 - 80 ℃; for 22h;

Reference yield:

→ (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine (1059182-91-0)

Guidance literature:

Reference yield:

(6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine (1059182-91-0) + 2-(tert-butoxycarbonylamino)-2-phenylacetic acid (2900-27-8,3601-66-9,14675-97-9,33125-05-2) → (R,S)-2-amino-N-(6-methoxy-pyridin-3-yl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide (1201195-11-0)

Guidance literature:

(6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine; 2-(tert-butoxycarbonylamino)-2-phenylacetic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In ethyl acetate; at 0 - 20 ℃;

With trifluoroacetic acid; In dichloromethane; ethyl acetate; for 4h;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

6-methoxy-pyridin-3-ylamine

4-Trifluoromethylphenylacetic acid

Downstream raw materials:

(R,S)-2-amino-N-(6-methoxy-pyridin-3-yl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide

(R,S)-2-Amino-2-(2-methoxy-phenyl)-N-(6-methoxy-pyridin-3-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide