Technology Process of 2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid
There total 6 articles about 2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid methyl ester;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 70 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / toluene / 12 h / Reflux
2: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
3: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
4: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
With
triethylsilane; water; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide;
ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; methanol; toluene;
2: Diels-Alder Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
2: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
3: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
With
triethylsilane; water; trifluoroacetic acid; sodium hydroxide;
ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; methanol;
1: Diels-Alder Reaction;
