(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

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Chemical Name:(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone
CAS No.:1343458-62-7
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

Synonyms:(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

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Chemical Property of (3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

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Technology Process of (3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

There total 6 articles about (3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1312756-35-6,392338-65-7
3-hydroxy-3-methylpyrrolidine

: 1343458-73-0
2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid

: 1343458-62-7
(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1343458-62-7
(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 16 h / 25 °C

3: triethylsilane; trifluoroacetic acid / 3 h / 25 °C

4: water; sodium hydroxide / tetrahydrofuran; methanol / 6 h / 70 °C

5: triethylamine; HATU / dichloromethane / 20 °C

With triethylsilane; water; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; ytterbium(III) trifluoromethanesulfonate nonohydrate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1343458-62-7
(3-hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 16 h / 25 °C

3: triethylsilane; trifluoroacetic acid / 3 h / 25 °C

4: water; sodium hydroxide / tetrahydrofuran; methanol / 6 h / 70 °C

5: triethylamine; HATU / dichloromethane / 20 °C

With triethylsilane; water; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; ytterbium(III) trifluoromethanesulfonate nonohydrate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;