(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

Base Information

Chemical Name:(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine
CAS No.:1416980-06-7
Molecular Formula:C₁₈H₁₄Cl₂F₄N₂
Molecular Weight:405.222
Hs Code.:

Synonyms:(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

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Chemical Property of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

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Technology Process of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

There total 8 articles about (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416980-08-9
5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

: 1416980-06-7
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

Guidance literature:: With ammonium chloride; zinc; In methanol; water; at 20 ℃; for 3h;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1416980-06-7
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium cyanoborohydride; acetic acid / 3.33 h / 10 - 20 °C

2.1: dmap / acetonitrile / 16 h / 20 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

4.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.2: 2 h / 20 °C

6.1: hydrogenchloride; sodium nitrite / water / 2 h / 20 °C

7.1: zinc; ammonium chloride / water; methanol / 3 h / 20 °C

With hydrogenchloride; dmap; sodium cyanoborohydride; potassium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; zinc; sodium nitrite; [2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride; In methanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 1158744-48-9
tert-Butyl 5-vinylindoline-1-carboxylate

: 1416980-06-7
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 2 h / 20 °C

4.1: zinc; ammonium chloride / water; methanol / 3 h / 20 °C

With hydrogenchloride; ammonium chloride; trifluoroacetic acid; zinc; sodium nitrite; [2,2]bipyridinyl; copper(l) chloride; In methanol; dichloromethane; water; 1,2-dichloro-benzene;