5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

Base Information

Chemical Name:5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline
CAS No.:1416980-08-9
Molecular Formula:C₁₈H₁₂Cl₂F₄N₂O
Molecular Weight:419.206
Hs Code.:

Synonyms:5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

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Chemical Property of 5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

Chemical Property:

Purity/Quality:

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Technology Process of 5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

There total 7 articles about 5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22190-33-6
5-bromoindoline

: 1416980-08-9
5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / acetonitrile / 16 h / 20 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

3.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

5.1: hydrogenchloride; sodium nitrite / water / 2 h / 20 °C

With hydrogenchloride; dmap; potassium carbonate; trifluoroacetic acid; sodium nitrite; [2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride; In dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 261732-38-1
tert-butyl 5-bromoindoline-1-carboxylate

: 1416980-08-9
5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

2.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: hydrogenchloride; sodium nitrite / water / 2 h / 20 °C

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; sodium nitrite; [2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride; In dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-benzene;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1416980-08-9
5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium cyanoborohydride; acetic acid / 3.33 h / 10 - 20 °C

2.1: dmap / acetonitrile / 16 h / 20 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

4.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.2: 2 h / 20 °C

6.1: hydrogenchloride; sodium nitrite / water / 2 h / 20 °C

With hydrogenchloride; dmap; sodium cyanoborohydride; potassium carbonate; acetic acid; trifluoroacetic acid; sodium nitrite; [2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride; In dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-benzene; acetonitrile;