(2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid

Base Information

• Chemical Name: (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid
• CAS No.: 1416820-82-0
• Molecular Formula: C₂₀H₂₂O₆
• Molecular Weight: 358.391
• Mol file: 1416820-82-0.mol

Synonyms:(2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid

Chemical Property of (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid

There total 5 articles about (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate (1416820-81-9) → (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid (1416820-82-0)

Guidance literature:

ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate; With lithium hydroxide; In methanol; water; for 3h; pH=10;

With hydrogenchloride; In methanol; water; pH=3 - 4;

Reference yield:

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate (222555-06-8) → (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid (1416820-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: lithium hydroxide / methanol / 3 h / pH 10

2.2: pH 3 - 4

With potassium carbonate; lithium hydroxide; In methanol; acetone;

Reference yield:

ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate (251454-50-9) → (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid (1416820-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 1551.49 Torr

2.1: potassium carbonate / acetone / 20 °C

3.1: lithium hydroxide / methanol / 3 h / pH 10

3.2: pH 3 - 4

With hydrogen; potassium carbonate; lithium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; acetone;

upstream raw materials:

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate

(S)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoic acid

ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate