ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate

Base Information

• Chemical Name: ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate
• CAS No.: 1416820-81-9
• Molecular Formula: C₂₂H₂₆O₆
• Molecular Weight: 386.445
• Mol file: 1416820-81-9.mol

Synonyms:ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate

Chemical Property of ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate

There total 3 articles about ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-bromo-3'-methoxyacetophenone (5000-65-7) + ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate (222555-06-8) → ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate (1416820-81-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

Reference yield:

(S)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoic acid (162919-37-1) → ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate (1416820-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 1551.49 Torr

3: potassium carbonate / acetone / 20 °C

With hydrogen; potassium carbonate; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; acetone;

Reference yield:

3-(4-benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester (267228-40-0) → ethyl (2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate (1416820-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3: potassium carbonate / acetone / 20 °C

With palladium 10% on activated carbon; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; In ethanol; dichloromethane; acetone;

upstream raw materials:

2-bromo-3'-methoxyacetophenone

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

(S)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoic acid

3-(4-benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester

Downstream raw materials:

(2S)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid