(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

Base Information

Chemical Name:(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane
CAS No.:259249-31-5
Molecular Formula:C₅₂H₆₅NO₅S₂Si₂
Molecular Weight:904.395
Hs Code.:

Synonyms:(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

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Technology Process of (R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

There total 1 articles about (R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 540-63-6
ethane-1,2-dithiol

: (R)-2-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-1-(4-methoxy-phenyl)-piperidin-4-one

: 259249-31-5
(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.3987/COM-99-S47

Reference yield: 83.0%

: 259249-31-5
(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

: 259249-38-2
{(4S,5S)-5-Hydroxymethyl-2-[(R)-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]dec-7-yl]-2-methyl-[1,3]dioxolan-4-yl}-methanol

Guidance literature:: With n-Bu₄NH; In tetrahydrofuran;
DOI:10.3987/COM-99-S47

Reference yield:

: 259249-31-5
(R)-7-[(4S,5S)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-[1,3]dioxolan-2-yl]-8-(4-methoxy-phenyl)-1,4-dithia-8-aza-spiro[4.5]decane

: 259249-36-0
1-(4-methoxyphenyl)-2-propylpiperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / n-Bu₄NH / tetrahydrofuran

2: 13 percent / CBr₄; Ph₃P / CH₂Cl₂

3: 95 percent / Zn-Cu / methanol

4: 22 percent / KHMDS / tetrahydrofuran

5: 53 percent / BF₃*OEt₂ / CH₂Cl₂

6: 71 percent / Raney Ni W₄ / ethanol

With carbon tetrabromide; n-Bu₄NH; Raney Ni W₄; boron trifluoride diethyl etherate; potassium hexamethylsilazane; copper; triphenylphosphine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: desilylation / 2: Bromination / 3: Decomposition / 4: Methylation / 5: Cycloaddition / 6: Reduction;
DOI:10.3987/COM-99-S47