259249-36-0Relevant articles and documents
Enantioselective syntheses of ent-sedridine and (+)-coniine via proline-catalyzed mannich reaction
Nagata, Kazuhiro,Nishimura, Kosuke,Yokoya, Masashi,Itoh, Takashi
, p. 335 - 344 (2007/10/03)
Proline-catalyzed three component Mannich reaction using 5-hydroxypentanal as a substrate was achieved in high enantioselectivity to construct a chiral center at C-2 position of 2-substituted piperidine alkaloids. The method was applied to the total syntheses of ent-sedridine and (+)-coniine.