2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

Base Information

• Chemical Name: 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one
• CAS No.: 121187-69-7
• Molecular Formula: C₁₆H₁₈N₄O₃
• Molecular Weight: 314.344
• Mol file: 121187-69-7.mol

Synonyms:2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

Chemical Property of 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

There total 4 articles about 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-amino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (121187-68-6) → 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (121187-69-7)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 3.5h;

DOI:10.1002/jhet.5570260247

Reference yield:

2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (1029-52-3) → 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (121187-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / 1 N HCl, H₂ / 10 percent Pd/C / propan-2-ol; H₂O / 7 h

2: 46 percent / NaOAc, KI / dimethylsulfoxide / 96 h / 75 °C

3: 94 percent / 0.5 N NaOH / 3.5 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium acetate; potassium iodide; palladium on activated charcoal; In water; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1002/jhet.5570260247

Reference yield:

4-bromoethylbenzoic acid ethyl ester (74003-31-9) → 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (121187-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / NaOAc, KI / dimethylsulfoxide / 96 h / 75 °C

2: 94 percent / 0.5 N NaOH / 3.5 h / 20 °C

With sodium hydroxide; sodium acetate; potassium iodide; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570260247

upstream raw materials:

2-amino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

4-bromoethylbenzoic acid ethyl ester

2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

2-amino-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one dihydrochloride