1029-52-3

Basic information

• Product Name: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE
• Synonyms: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE;2-AMino-6-benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one;2-amino-6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(1H)-one
• CAS NO: 1029-52-3
• Molecular Formula: C₁₄H₁₆N₄O
• Molecular Weight: 256.3
• Mol File: 1029-52-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE(1029-52-3)
• EPA Substance Registry System: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE(1029-52-3)

Safety Data

• Hazardous Substances Data: 1029-52-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE is a chemical compound that belongs to the pyrido[4,3-d]pyrimidin-4(3H)-one family. It consists of a pyrido[4,3-d]pyrimidin-4(3H)-one core with an amino group at the 2-position, a phenylmethyl group at the 6-position, and a tetrahydro-6-membered ring. 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE has potential biological activity and can be used in the development of pharmaceutical drugs. Its chemical structure makes it a potentially interesting molecule for further research in the fields of medicinal and pharmaceutical chemistry.

Upstream product

• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 50-01-1 guanidine hydrochloride 
• 593-85-1 diguanidine carbonate 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 124-46-9 guanidine hydrogen carbonate 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 113-00-8 guanidine nitrate 

Downstream Products

• 121187-71-1 2-amino-6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine hydrochloride 
• 570415-48-4 6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 
• 1449500-83-7 tert-butyl (6-benzyl-4-((tert-butoxycarbonyl)(butyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(tert-butoxycarbonyl)carbamate 
• 1449500-81-5 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine 
• 121187-70-0 (S)-2-{4-[2-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 121187-76-6 (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 121187-65-3 (S)-2-{4-[2-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid 
• 121187-66-4 (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid 
• 121187-74-4 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 
• 121187-68-6 2-amino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one 
• 121187-75-5 2,4-diamino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 
• 121187-69-7 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one 
• 121187-72-2 2-amino-6-benzyl-4-hydrazino-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 

Relevant articles and documents

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists

In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure–activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high clearance profile resulted in the identification of compound 52a1. Evaluation in vivo revealed an interferon stimulated response (ISG) in mice with limited systemic exposure and demonstrated the potential in antiviral treatment or as a vaccine adjuvant.

PIPERIDINO-PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

2-Amino-6-iodo-4-tosyloxypyrimidine: a versatile key intermediate for regioselective functionalization of 2-aminopyrimidines in 4- and 6-positions

2-Amino-6-iodo-4-tosyloxypyrimidine, easily prepared from commercially available material, is a key intermediate for the preparation of differentially substituted 2-aminopyrimidines by means of sequenced Suzuki and/or Sonogashira reactions.