1029-52-3

Usage

Uses

Used in Pharmaceutical Development:
2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE is used as a pharmaceutical precursor for the development of new drugs. Its unique structure and potential biological activity make it a valuable compound for creating innovative medications to address various health conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE serves as a key molecule for studying its interactions with biological targets. This research can lead to a better understanding of its therapeutic potential and the discovery of new drug candidates with improved efficacy and safety profiles.
Used in Drug Design and Optimization:
2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE is utilized in drug design and optimization processes to create more effective and targeted pharmaceutical agents. Its unique features can be leveraged to design drugs with enhanced potency, selectivity, and reduced side effects, ultimately benefiting patients and advancing the field of medicine.

Upstream product

• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 113-00-8 guanidine nitrate 
• 124-46-9 guanidine hydrogen carbonate 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 593-85-1 diguanidine carbonate 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 50-01-1 guanidine hydrochloride 

Downstream Products

• 1449500-83-7 tert-butyl (6-benzyl-4-((tert-butoxycarbonyl)(butyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(tert-butoxycarbonyl)carbamate 
• 1449500-81-5 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine 
• 570415-48-4 6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 
• 121187-70-0 (S)-2-{4-[2-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 121187-76-6 (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 121187-65-3 (S)-2-{4-[2-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid 
• 121187-66-4 (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid 
• 121187-74-4 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 
• 121187-68-6 2-amino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one 
• 121187-75-5 2,4-diamino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 
• 121187-69-7 2-amino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one 
• 121187-72-2 2-amino-6-benzyl-4-hydrazino-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine 
• 121187-71-1 2-amino-6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine hydrochloride 

Relevant academic research and scientific papers

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists

In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure–activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high clearance profile resulted in the identification of compound 52a1. Evaluation in vivo revealed an interferon stimulated response (ISG) in mice with limited systemic exposure and demonstrated the potential in antiviral treatment or as a vaccine adjuvant.

Piperidino-pyrimidine derivatives for the treatment of viral infections

This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

PIPERIDINO-PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS

The present invention provides isoquinoline, tetrahydroisoquinoline and tetrahydropyridopyrimidine compounds that induce cell death by apoptosis and uses of the compounds in medicine, expecially their use for treating cancer and other diseases.

2-Amino-6-iodo-4-tosyloxypyrimidine: a versatile key intermediate for regioselective functionalization of 2-aminopyrimidines in 4- and 6-positions

2-Amino-6-iodo-4-tosyloxypyrimidine, easily prepared from commercially available material, is a key intermediate for the preparation of differentially substituted 2-aminopyrimidines by means of sequenced Suzuki and/or Sonogashira reactions.