1-(2-PYRIDYL)PIPERAZINE MONOHYDROCHLORIDE

Base Information

• Chemical Name: 1-(2-PYRIDYL)PIPERAZINE MONOHYDROCHLORIDE
• CAS No.: 129394-11-2
• Molecular Formula: C₉H₁₃N₃*2ClH
• Molecular Weight: 236.144
• Hs Code.: 29183000
• Mol file: 129394-11-2.mol

Synonyms:Piperazine,1-(2-pyridinyl)-, monohydrochloride (9CI);1-(2-Pyridyl)piperazinehydrochloride;2-(Piperazin-1-yl)pyridine monohydrochloride;

Chemical Property of 1-(2-PYRIDYL)PIPERAZINE MONOHYDROCHLORIDE

Chemical Property:

• Appearance/Colour: Gray power
• Vapor Pressure: 4.57E-05mmHg at 25°C
• Melting Point: 232-233 °C(Solv: ethanol (64-17-5))
• Boiling Point: 344.7 °C at 760 mmHg
• Flash Point: 162.3 °C
• PSA: 28.16000
• Density: 1.19?g/mL?at 25?°C(lit.)
• LogP: 1.68700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Pyridyl)piperazine Monohydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-PYRIDYL)PIPERAZINE MONOHYDROCHLORIDE

There total 3 articles about 1-(2-PYRIDYL)PIPERAZINE MONOHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate (77278-62-7) → 1-(pyridin-2-yl)-piperazine hydrochloride (52266-53-2,129394-11-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

2-aminopyridine (504-29-0) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) → 1-(pyridin-2-yl)-piperazine hydrochloride (52266-53-2,129394-11-2)

Guidance literature:

With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃;

DOI:10.1016/j.bmc.2016.09.005

Reference yield:

→ 1-(pyridin-2-yl)-piperazine hydrochloride (52266-53-2,129394-11-2)

Guidance literature:

upstream raw materials:

2-aminopyridine

bis-(2-chloroethyl)amine hydrochloride

tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate

Downstream raw materials:

1-phenyl-3-(4-pyridin-2-yl-piperazin-1-yl)-propan-1-one

1-(4-fluorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)ethanone

1-(2-(bis(4-flurophenyl)methoxy)ethyl)-4-(pyridine-2-yl)piperazine

C₂₉H₃₆N₄O₂S

Refernces

• 1、 -. "POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS". Page/Page column 87; 88. . Retrieved 2018/07/29.
• 2、 -. "THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION". Page/Page column 101. . Retrieved 2011/06/26.