(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Base Information

Chemical Name:(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide
CAS No.:1206635-29-1
Molecular Formula:C₁₅H₂₁ClN₂O₄
Molecular Weight:328.796
Hs Code.:

Synonyms:(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Chemical Property:

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Technology Process of (R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

There total 1 articles about (R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2
(R)-N-tert-butoxycarbonyl serine

: 42365-43-5
(4-chlorophenyl)methanamine hydrochloride

: 1206635-29-1
(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Guidance literature:: (R)-N-tert-butoxycarbonyl serine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

(4-chlorophenyl)methanamine hydrochloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm901563p

Reference yield: 56.0%

: 1206635-29-1
(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

: 74-88-4
methyl iodide

: 1206635-30-4
(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-methoxypropionamide

Guidance literature:: With silver(l) oxide; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere; Darkness;
DOI:10.1021/jm901563p

Reference yield:

: 1206635-29-1
(R)-N-4-(chloro)benzyl 2-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

: 1206634-98-1
(R)-N-4-(chloro)benzyl 2-acetamido-3-methoxypropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(l) oxide / acetonitrile / 48 h / 20 °C / Inert atmosphere; Darkness

2.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C

2.2: 0 - 20 °C

With hydrogenchloride; silver(l) oxide; In 1,4-dioxane; acetonitrile;