(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

Chemical Name:(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS No.:1452849-72-7
Molecular Formula:C₂₂H₂₅N₃O₄S₃
Molecular Weight:491.656
Hs Code.:

Synonyms:(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

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Chemical Property of (Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

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Technology Process of (Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 3 articles about (Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1452776-83-8
tert-butyl 2-(3-(4-cyanobenzenesulfonyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 74-88-4
methyl iodide

: 1452849-72-7
(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jo4010876

Reference yield:

: 92932-02-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid tert-butyl ester

: 1452849-72-7
(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: calcium carbonate / water; dichloromethane / 0.67 h / 0 °C

2: potassium carbonate / acetone / 20 h / Reflux

3: water; sodium hydroxide / ethanol / 2 h / 20 °C

With water; potassium carbonate; calcium carbonate; sodium hydroxide; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo4010876

Reference yield:

: 207743-78-0
tert-butyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylate

: 1452849-72-7
(Z)-tert-butyl 2-((4-cyanobenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 h / Reflux

2: water; sodium hydroxide / ethanol / 2 h / 20 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; acetone;
DOI:10.1021/jo4010876