3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester
• CAS No.: 122957-13-5
• Molecular Formula: C₁₉H₁₉N₃O₃
• Molecular Weight: 337.378

Synonyms:3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester

Chemical Property of 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester

There total 5 articles about 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-nitropyridine (13091-23-1) → 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester (122957-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 45 percent / propionic acid / 4 h / 120 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; ethanol; dichloromethane; propionic acid;

DOI:10.1021/jm00095a005

Reference yield:

4-[N-(4-cyanophenyl)amino]-3-nitropyridine (122957-33-9) → 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester (122957-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

2: 45 percent / propionic acid / 4 h / 120 °C

3: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; dichloromethane; propionic acid;

DOI:10.1021/jm00095a005

Reference yield:

4-Aminobenzonitrile (873-74-5) → 3-[4-(2-Ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester (122957-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 45 percent / propionic acid / 4 h / 120 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; ethanol; dichloromethane; propionic acid;

DOI:10.1021/jm00095a005

upstream raw materials:

ethyl bromoacetate

1-(4-cyanophenyl)-2-ethylimidazo<4,5-c>pyridine

4-chloro-3-nitropyridine

3-amino-4-[N-(4-cyanophenyl)amino]pyridine

Downstream raw materials:

4-(2-Chloro-phenyl)-2-[4-(2-ethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-6-methyl-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

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