2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid methyl ester
• CAS No.: 960198-51-0
• Molecular Formula: C₁₂H₉FN₂O₂
• Molecular Weight: 232.214
• Mol file: 960198-51-0.mol

Synonyms:2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid methyl ester

Chemical Property of 2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid methyl ester

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Methyl2-(3-fluorophenyl)pyrimidine-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid methyl ester

There total 1 articles about 2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

3-fluorobenzenecarboximidamide hydrochloride (75207-72-6) + sodium 2-(dimethoxymethyl)-3-methoxy-3-oxoprop-1-en-1-olate → 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid methyl ester (960198-51-0)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield: 98.0%

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid methyl ester (960198-51-0) → 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid (933988-24-0)

Guidance literature:

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid methyl ester; With methanol; lithium hydroxide; at 20 ℃;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid methyl ester (960198-51-0) → 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid chloride (933989-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; lithium hydroxide / 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 - 3.5 h / 0 - 20 °C

With methanol; lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

3-fluorobenzenecarboximidamide hydrochloride

Downstream raw materials:

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid chloride

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid pyrrolo[3,2-b]pyridin-1-ylamide

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide