3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate

Base Information

• Chemical Name: 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate
• CAS No.: 1123661-03-9
• Molecular Formula: C₂HF₃O₂*C₂₁H₂₂N₂O₂
• Molecular Weight: 448.442
• Mol file: 1123661-03-9.mol

Synonyms:3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate

Chemical Property of 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate

There total 2 articles about 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-benzyloxy-3-cyanophenyl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester + trifluoroacetic acid (76-05-1) → 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate (1123661-03-9)

Guidance literature:

3-(2-benzyloxy-3-cyanophenyl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester; trifluoroacetic acid; In dichloromethane; for 1h;

With water; hydrido(dimethylphosphonious acid-kP)[hydrogen bis(dimethylphosphinito-kP)]platinum(II); In ethanol; at 75 ℃;

Reference yield:

2-benzyloxy-3-bromo-benzamide (862992-92-5) + 3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester (900503-08-4) + trifluoroacetic acid (76-05-1) → 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-hydroxybenzamide trifluoroacetate (1123661-07-3) + 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate (1123661-03-9)

Guidance literature:

2-benzyloxy-3-bromo-benzamide; 3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; Heating / reflux;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-hydroxybenzamide trifluoroacetate (1123661-07-3) + 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate (1123661-03-9) → 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide trifluoroacetate (1123661-10-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; Product distribution / selectivity;

upstream raw materials:

2-benzyloxy-3-bromo-benzamide

3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester

trifluoroacetic acid

Downstream raw materials:

3-endo-(8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide trifluoroacetate