(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Base Information

Chemical Name:(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol
CAS No.:208044-44-4
Molecular Formula:C₃₂H₄₆O₈
Molecular Weight:558.712
Hs Code.:

(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Synonyms:(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Suppliers and Price of (3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

There total 9 articles about (3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 208044-43-3
(3S,4aR,6R,9S,10R,11S,12R,12aR)-dodecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8(2H)-one

: 208044-44-4
(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃;
DOI:10.1021/ja980538t

Reference yield:

: (3S,4aR,6S,10S,11R,12R,12aR)-dodecahydro-11,12-(isopropylidenedioxy)-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-7(1H)-one

: 208044-44-4
(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) 18-crown-6, O₂, 2.) potassium hexamethyldisilazide / 1.) THF, 30 min, 2.) THF, toluene, 0 deg C, 10 min

2: 65 percent / lithium aluminum hydride / diethyl ether / 0.5 h / 25 °C

3: 85 percent / 4-(dimethylamino)pyridine, pyridine / 25 °C

4: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 3 min, 2.) THF, from -78 deg C to RT, 1 h

5: 92 percent / 30percent aq. H₂O₂, AcOH / tetrahydrofuran / 1 h / 0 °C

6: 82 percent / SmI₂ / tetrahydrofuran; methanol / -78 °C

7: 1.) pyridine, OsO₄, 2.) aq. NaHSO₃ / 1.) THF, -18 deg C, 2 h, 2.) THF, overnight

8: 100 percent / camphorsulfonic acid / dimethylformamide / 6 h / 50 - 55 °C

9: 93 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0 °C

With pyridine; dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; samarium diiodide; 18-crown-6 ether; camphor-10-sulfonic acid; dihydrogen peroxide; oxygen; potassium hexamethylsilazane; sodium hydrogensulfite; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja980538t

Reference yield:

: 208044-30-8
(3S,4aR,6R,9Z,11R,12R,12aR)-1,3,4,4a,5,6,7,11,12,12a-decahydro-11,12-(isopropylidenedioxy)-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8(2H)-one

: 208044-44-4
(3S,4aR,6R,9R,10S,11S,12R,12aR)-tetradecahydro-11,12-(isopropylidenedioxy)-9,10-[(R)-(p-methoxybenzylidene)dioxy]-3-(methoxymethoxy)-12a,13,13-trimethyl-4-methylene-6,10-methanobenzocyclodecen-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine, OsO₄, 2.) aq. NaHSO₃ / 1.) THF, -18 deg C, 2 h, 2.) THF, overnight

2: 100 percent / camphorsulfonic acid / dimethylformamide / 6 h / 50 - 55 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0 °C

With pyridine; osmium(VIII) oxide; lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium hydrogensulfite; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja980538t