4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Base Information

Chemical Name:4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile
CAS No.:636595-74-9
Molecular Formula:C₂₈H₂₅F₃N₄O₅
Molecular Weight:554.526
Hs Code.:

4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Synonyms:4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Suppliers and Price of 4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

There total 6 articles about 4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 636595-66-9
6-(4-bromobut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one

: 636595-74-9
4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Guidance literature:: 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

6-(4-bromobut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1021/jm0303305

Reference yield:

: 77-71-4
5,5-dimethyl-imidazolidine-2,4-dione

: 636595-74-9
4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / K₂CO₃ / dimethylformamide / 64 h / 55 - 65 °C

2.1: NaH / dimethylformamide / 3 h / 20 °C

2.2: 82 percent / dimethylformamide / 6 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0303305

Reference yield:

: 76143-20-9
5-formyl-2-hydroxy-benzamide

: 636595-74-9
4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: decaborane / 5 h / 60 °C

2.1: 233 mg / p-TsOH / acetone / 1.5 h / 85 °C

3.1: pyridine; Et₃N / tetrahydrofuran / 1 h / 20 °C

4.1: 162 mg / LiBr / tetrahydrofuran

5.1: NaH / dimethylformamide / 3 h / 20 °C

5.2: 82 percent / dimethylformamide / 6 h / 20 °C

With pyridine; Decaborane; sodium hydride; toluene-4-sulfonic acid; triethylamine; lithium bromide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0303305