ACETIC ACID

Base Information

• Chemical Name: ACETIC ACID
• CAS No.: 55896-93-0
• Molecular Formula: C4H7ClO4S
• Molecular Weight: 186.616
• Hs Code.: 2915900090
• Mol file: 55896-93-0.mol

Synonyms:Acetic acid,(chlorosulfonyl)-, ethyl ester (9CI);(Chlorosulfonyl)acetic acid ethyl ester;2-(Chlorosulfonyl)acetic acid ethyl ester;Ethoxycarbonylmethanesulfonylchloride;Ethyl 2-(chlorosulfonyl)acetate;Ethyl2-(chlorosulfonyl)ethanoate;

Chemical Property of ACETIC ACID

Chemical Property:

• Vapor Pressure: 11.4 mm Hg ( 20 °C)
• Melting Point: 16.2 °C(lit.)
• Refractive Index: n20/D 1.371(lit.)
• Boiling Point: 244.28 °C at 760 mmHg
• PKA: 4.76(at 25℃)
• Flash Point: 101.537 °C
• PSA: 68.82000
• Density: 1.43 g/cm³
• LogP: 1.19890
• Storage Temp.: -196°C
• Solubility.: Benzene, Chloroform

Purity/Quality:

99.9% ^*data from raw suppliers

ChlorosulfonylAceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 34-41
• Safety Statements: 23-26-45-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used in the manufacture of vinyl acetate monomer (VAM), this accounts for one-third of acetic acid consumption. As a food additive (condiment, ingredient) or as a preservative, it is found in Vinegar solutions, usually between 3-9% in concentration. In the production of various synthetic materials, acetic acid is a precursor and solvent for various glues and plastics such as polyvinyl acetate, cellulose acetate, nylon and dimethyl terephthalate. As an agent widely used in the manufacture of organic compounds which are constituent parts of food ingredients, various dye stuffs and perfumes, Rayon fibre, synthetic fibres and textiles, inks and dyes, soft drinks bottles, rubbers and plactics, and pesticides. In waste water treatment, acetic acid may be dosed to correct highly alkaline pH from where caustic soda has been dosed to the fluid stream. For testing blood in clinical laboratory For the treatment of outer ear infections from the growth of fungus and bacteria Pharmaceutic aid (acidifying agent). Acetic Acid is an acid produced chemically from the conversion of alcohol to acetaldehyde to acetic acid. it is the principal component of vinegar which contains not less than 4 g of acetic acid in 100 cm3 at 20°c. the approved salts include sodium acetate, calcium acetate, sodium diacetate, and calcium diacetate. it is used as a preservative, acidulant, and flavoring agent in catsup, mayonnaise, and pickles. it can be used in conjunction with leavening agents to release carbon dioxide from sodium bicarbonate. Colorless liquid prepared by the distillation of wood or the oxidation of dilute ethyl alcohol. Acetic acid has a very pungent smell, and the vapors are flammable. When obtained in full strength (99 percent), it congeals as an ice-like solid at 16.7°C. For this reason the term glacial is also used to describe this acid. It is soluble in water, alcohol, ether, chloroform, and gelatin. Acetic acid was used as a restrainer for the physical development of calotypes, Niépceotypes, and collodion plates. Photographers also used it to retard non-image reduction of these processes by adding it to the silver nitrate solution. Acetic acid is used as a stop bath and as a solvent for gelatin.
• Indications: This product has anti-bacterial and fungal infections. 2% to 5% solution has a bactericidal effect on Haemophilus and Pseudomonas. It also has effect on Candida, Aspergillus and Trichomonas. It also has spermicidal effect. Various concentrations can be used for the treatment of various skins shallow bacterial or fungal infections, but also for vaginal trichomoniasis, burn wound infection, prevention of flu or flu and contraception.

Technology Process of ACETIC ACID

There total 6 articles about ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sodium 2-ethoxy-2-oxoethane-1-sulfonate (22128-42-3) → ethyl 2-(chlorosulfonyl)acetate (55896-93-0)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 2h;

DOI:10.3390/molecules18032864

Reference yield: 80.0%

acetic acid ethylester sulfonic acid (89124-45-8) → ethyl 2-(chlorosulfonyl)acetate (55896-93-0)

Guidance literature:

With trichlorophosphate;

Reference yield: 70.0%

ethyl 2-sulfanylacetate (623-51-8) → ethyl 2-(chlorosulfonyl)acetate (55896-93-0)

Guidance literature:

With water; chlorine; In dichloromethane; at 30 ℃; for 1h; Cooling with acetone-dry ice;

DOI:10.1021/ja1068036

upstream raw materials:

ethanol

chlorosulfonylacetyl chloride

acetic acid ethylester sulfonic acid

sodium 2-ethoxy-2-oxoethane-1-sulfonate

Downstream raw materials:

Ethyl-N-(o-nitrophenyl)-N-methyl-sulfamoylacetat

[(4-chloro-2-nitro-phenyl)-methyl-sulfamoyl]-acetic acid

[(2-amino-phenyl)-phenyl-sulfamoyl]-acetic acid

[(2-Nitro-phenyl)-phenyl-sulfamoyl]-acetic acid ethyl ester

Refernces

• 1、 Fang, Wan-Yin,Wang, Shi-Meng,Zhang, Zai-Wei,Qin, Hua-Li. "Clickable transformation of nitriles (RCN) to oxazolyl sulfonyl fluoride warheads". supporting information. p. 8904 - 8909. Retrieved 2020/11/30.
• 2、 Górski, Bartosz,Basiak, Dariusz,Talko, Alicja,Basak, Tymoteusz,Mazurek, Tomasz,Barbasiewicz, Micha?. "Olefination with Sulfonyl Halides and Esters: E-Selective Synthesis of Alkenes from Semistabilized Carbanion Precursors". supporting information. p. 1774 - 1784. Retrieved 2018/04/27.