7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one

Base Information

• Chemical Name: 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one
• CAS No.: 864829-37-8
• Molecular Formula: C₂₃H₂₆N₂O₂
• Molecular Weight: 362.472
• Mol file: 864829-37-8.mol

Synonyms:7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one

Chemical Property of 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one

There total 13 articles about 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-methylphenyl)piperidine hydrogen chloride salt (82212-02-0) + 9-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-7-carboxylic acid monohydrochloride (1206157-97-2) → 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one (864829-37-8)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 8h;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one (864829-37-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.67 h / 0 °C

1.2: 2 h / 80 °C

2.1: formic acid; hydrogen / palladium 10% on activated carbon / ethanol; water / 23 h / 20 °C / 2280.15 Torr

3.1: hydrogenchloride / ethyl acetate / 20 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 8 h / 20 °C

With pyridine; hydrogenchloride; formic acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; ethyl acetate;

Reference yield:

4-(2-methylphenyl)piperidine hydrogen chloride salt (82212-02-0) + C11H11NO3 (1206229-65-3) → 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one (864829-37-8)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 8h;

DOI:10.1021/jm701590h

upstream raw materials:

4-(2-methylphenyl)piperidine hydrogen chloride salt

9-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-7-carboxylic acid monohydrochloride

C₁₁H₁₁NO₃

1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-pyridine