ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Base Information

Chemical Name:ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate
CAS No.:1403655-79-7
Molecular Formula:C₂₁H₁₈F₃NO₃
Molecular Weight:389.374
Hs Code.:

Synonyms:ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Suppliers and Price of ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

There total 2 articles about ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.2%

: 56999-62-3
ethyl 2-(1-methyl-1H-indol-3-yl)acetate

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1403655-79-7
ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Guidance literature:: ethyl 2-(1-methyl-1H-indol-3-yl)acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

4-trifluoromethyl-phenyl acetyl chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.2174/157018012802652912

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 1403655-79-7
ethyl 2-(1-methyl-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.2174/157018012802652912