(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

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Chemical Name:(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone
CAS No.:1026560-28-0
Molecular Formula:C₂₆H₂₆FN₃O₂
Molecular Weight:431.51
Hs Code.:

Synonyms:(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

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Chemical Property of (4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

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Technology Process of (4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

There total 5 articles about (4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68281-42-5
ethyl 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate

: 1026560-28-0
(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 2N aq. NaOH / 2 h / Heating

2: Et₃N / CHCl₃ / 0.08 h / 0 °C

3: CHCl₃ / 12 h / Ambient temperature

With sodium hydroxide; triethylamine; In chloroform;
DOI:10.1021/jm970795t

Reference yield:

: 100-39-0
benzyl bromide

: 1026560-28-0
(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / K₂CO₃ / acetone / 12 h / Heating

2: 88 percent / 2N aq. NaOH / 2 h / Heating

3: Et₃N / CHCl₃ / 0.08 h / 0 °C

4: CHCl₃ / 12 h / Ambient temperature

With sodium hydroxide; potassium carbonate; triethylamine; In chloroform; acetone;
DOI:10.1021/jm970795t

Reference yield:

: 212578-39-7
4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid

: 1026560-28-0
(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 0.08 h / 0 °C

2: CHCl₃ / 12 h / Ambient temperature

With triethylamine; In chloroform;
DOI:10.1021/jm970795t