(S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Base Information

Chemical Name:(S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride
CAS No.:204453-07-6
Molecular Formula:C₁₁H₁₄FNO₂*ClH
Molecular Weight:247.697
Hs Code.:

Synonyms:(S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Suppliers and Price of (S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

There total 2 articles about (S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33166-77-7
ethyl 3-(3-fluorophenyl)-3-oxopropanoate

: 204453-07-6
(S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Guidance literature:: ethyl 3-(3-fluorophenyl)-3-oxopropanoate; With C₇H₈*C₄₂H₃₈O₆P₂Ru; ammonium acetate; hydrogen; In 2,2,2-trifluoroethanol; at 75 ℃; for 30h; under 5931.67 Torr; Large scale reaction;

With hydrogenchloride; In isopropyl alcohol; optical yield given as %ee; Large scale reaction;
DOI:10.1021/op100020z

Reference yield:

: 451-02-5
ethyl 3-fluorobenzoate

: 204453-07-6
(S)-3-amino-3-(3-fluorophenyl)propionic acid ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -10 - -5 °C / Large scale reaction

2.1: C₇H₈*C₄₂H₃₈O₆P₂Ru; ammonium acetate; hydrogen / 2,2,2-trifluoroethanol / 30 h / 75 °C / 5931.67 Torr / Large scale reaction

2.2: Large scale reaction

With C₇H₈*C₄₂H₃₈O₆P₂Ru; potassium tert-butylate; ammonium acetate; hydrogen; In tetrahydrofuran; 2,2,2-trifluoroethanol;
DOI:10.1021/op100020z