(1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide

Base Information

• Chemical Name: (1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide
• CAS No.: 125224-64-8
• Molecular Formula: 2BrH*C₆H₁₂N₂
• Molecular Weight: 273.999
• Hs Code.: 2933998090
• European Community (EC) Number: 835-562-3
• Mol file: 125224-64-8.mol

Synonyms:125224-64-8;(1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide;(1R,4R)-2-METHYL-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHBR;2,5-Diazabicyclo[2.2.1]heptane, 2-methyl-, hydrobromide (1:2), (1R,4R)-;(1r,4r)-2-methyl-2,5-diazabicyclo[2.2.1]heptane 2hbr;(1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane;dihydrobromide;MFCD13195528;SCHEMBL20399053;AKOS015909942;AKOS016023666;AS-34295;EN300-70353;(1R,4R)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane diHCl;(R)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide;(1R,4R)-5-METHYL-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE

Chemical Property of (1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide

Chemical Property:

• Melting Point: 220-225 ºC
• PSA: 15.27000
• LogP: 1.84520
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 273.95032
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

(1R,4R)-5-Methyl-2,5-diazabicyclo[2.2.1]heptaneDihydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CC2CC1CN2.Br.Br
• Isomeric SMILES: CN1C[C@H]2C[C@@H]1CN2.Br.Br
• Uses: (1R,4R)-5-Methyl-2,5-diazabicyclo[2.2.1]heptane Dihydrobromide is used as a reactant in organic synthesis.

Technology Process of (1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide

There total 25 articles about (1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane (125224-63-7) → (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

With hydrogen bromide; acetic acid; Ambient temperature;

DOI:10.1021/jo00292a054

Reference yield: 81.0%

(1S,4S)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane (125109-58-2) → (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

With hydrogen bromide; acetic acid; for 6h; Ambient temperature;

DOI:10.1021/jo00292a054

Reference yield: 81.0%

→ (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

upstream raw materials:

(1S,4S)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane

(1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane

(2S,4R)-2-Hydroxymethyl-4-hydroxy-1-(4-toluenesulfonyl)-pyrrolidine

(2S,4R)-1-(4-tolylsulfonyl)-4-<(4-tolylsulfonyl)oxy>-2-<<(4-tolylsulfonyl)oxy>methyl>pyrrolidine

Downstream raw materials:

(1S,4S)-(+)-2,5-dimethyl-2,5-diazabicyclo[2.21]heptane

4-chloro-5-fluoro-6-((1S,4S)-5-methyl-2,5-diazazbicyclo[2.2.1]hept-2-yl)-2(1H)-pyrimidinone hydrazone

(1S,4S)-2-(2-chloro-5-fluoro-6-hydrazino-4-pyrimidinyl)-5-methyl-2,5-diazazbicyclo[2.2.1]heptane

2-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-5-nitrotoluene