1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Base Information

Chemical Name:1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide
CAS No.:1374452-61-5
Molecular Formula:C₂₂H₂₀FN₅O₂
Molecular Weight:405.432
Hs Code.:

Synonyms:1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Suppliers and Price of 1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

There total 5 articles about 1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1374452-63-7
(1-{4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

: 1374452-61-5
1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: (1-{4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 167631-84-7
5-fluoro-1H-indole-2-carboxylic acid methyl ester

: 1374452-61-5
1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / toluene / 24 h / Reflux

2: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 120 h / 20 °C / Molecular sieve

3: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 - 20 °C

5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper diacetate; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1253493-31-0
5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-1H-indole

: 1374452-61-5
1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 120 h / 20 °C / Molecular sieve

2: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 - 20 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper diacetate; In dichloromethane; N,N-dimethyl-formamide;