(S)-3-Bromo-1,2-propanediol

Base Information

• Chemical Name: (S)-3-Bromo-1,2-propanediol
• CAS No.: 137490-63-2
• Molecular Formula: C3H7BrO2
• Molecular Weight: 154.99
• Mol file: 137490-63-2.mol

Synonyms:1,2-Propanediol,3-bromo-, (S)-;(S)-(+)-3-Bromo-1,2-propanediol;(S)-3-Bromo-1,2-propanediol;

Chemical Property of (S)-3-Bromo-1,2-propanediol

Chemical Property:

• Vapor Pressure: 0.00273mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 254 °C at 760 mmHg
• PKA: 13.07±0.20(Predicted)
• Flash Point: 126.5 °C
• PSA: 40.46000
• Density: 1.789 g/cm³
• LogP: -0.26550
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Bromopropane-1,2-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Bromo-1,2-propanediol

There total 11 articles about (S)-3-Bromo-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(+)-3-bromo-1,2-propanediol (137490-63-2)

Guidance literature:

With C₁₀₈H₁₂₃Co₃N₆O₁₂; water; In tetrahydrofuran; water; at 20 ℃; for 168h;

DOI:10.1016/j.molcata.2014.09.012

Reference yield: 90.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(+)-3-bromo-1,2-propanediol (137490-63-2) + (R)-3-bromo-1,2-epoxypropane (51594-57-1,82584-73-4)

Guidance literature:

With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja016737l

Reference yield: 90.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(+)-3-bromo-1,2-propanediol (137490-63-2) + (R)-3-bromo-1,2-epoxypropane (51594-57-1,82584-73-4) + 1-bromo-2,3-epoxypropane (96479-96-8,82584-73-4)

Guidance literature:

With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/ja016737l

upstream raw materials:

(S)-1-bromo-2,3-bis-octadecanoyloxy-propane

1-bromo-2,3-propanediol

allyl bromide

(S)-oxiranemethanol

Downstream raw materials:

(S)-(4-bromomethyl)-2,2-dimethyl-1,3-dioxolane

Refernces

• 1、 Pecnikaj, Ilir,Foschi, Francesca,Bucci, Raffaella,Gelmi, Maria Luisa,Castellano, Carlo,Meneghetti, Fiorella,Penso, Michele. "Stereoselective Synthesis of α,α′-Dihydroxy-β,β′-diaryl-β-amino Acids by Mannich-Like Condensation of Hydroarylamides". supporting information. p. 6707 - 6713. Retrieved 2019/11/03.
• 2、 Dandachi, Hiba,Zaborova, Elena,Kolodziej, Emilie,David, Olivier R.P.,Hannedouche, Jér?me,Mellah, Mohamed,Jaber, Nada,Schulz, Emmanuelle. "Mixing and matching chiral cobalt- and manganese-based calix-salen catalysts for the asymmetric hydrolytic ring opening of epoxides". . p. 246 - 253. Retrieved 2017/03/01.