2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE

Base Information

• Chemical Name: 2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE
• CAS No.: 113428-57-2
• Molecular Formula: C6H11 Br O2
• Molecular Weight: 195.05
• Mol file: 113428-57-2.mol

Synonyms:1,3-Dioxolane,4-(bromomethyl)-2,2-dimethyl-, (S)-;(S)-4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane

Chemical Property of 2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE

Chemical Property:

• Vapor Pressure: 0.688mmHg at 25°C
• Refractive Index: 1.453
• Boiling Point: 192.2°C at 760 mmHg
• Flash Point: 74.8°C
• PSA: 18.46000
• Density: 1.359g/cm³
• LogP: 1.53280

Purity/Quality:

99% ^*data from raw suppliers

2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE

There total 4 articles about 2,2-DIMETHYL-4(S)-4-BROMOMETHYL-1,3-DIOXALANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-3-bromo-1,2-propanediol (137490-63-2) + 2,2-dimethoxy-propane (77-76-9) → (S)-(4-bromomethyl)-2,2-dimethyl-1,3-dioxolane (113428-57-2)

Guidance literature:

With amberlyst 15; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.molcata.2014.09.012

Reference yield:

1-bromo-2,3-propanediol (4704-77-2) + 2,2-dimethoxy-propane (77-76-9) → (R)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl bromide (14437-87-7) + (S)-(4-bromomethyl)-2,2-dimethyl-1,3-dioxolane (113428-57-2)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 0.5h; Title compound not separated from byproducts;

DOI:10.1002/adsc.200606181

Reference yield:

2,2-dimethoxy-propane (77-76-9) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(4-bromomethyl)-2,2-dimethyl-1,3-dioxolane (113428-57-2) + 1-bromo-2,3-epoxypropane (96479-96-8,82584-73-4)

Guidance literature:

1,2-Epoxy-3-bromopropane; With (S,S)-(N,N′-bis(3-tert-butylsalicylidene-5-(thiophen-2-yl)-cyclohexane-1,2-diamine)); C₃₆H₄₀ClMnN₂O₂S₂; In tetrahydrofuran; water; chlorobenzene; at 4 ℃; for 48h;

2,2-dimethoxy-propane; In dichloromethane; at 20 ℃; for 18h; Reagent/catalyst;

DOI:10.1039/c4cy00235k

upstream raw materials:

1-bromo-2,3-propanediol

2,2-dimethoxy-propane

1,2-Epoxy-3-bromopropane

(S)-(+)-3-bromo-1,2-propanediol

Downstream raw materials:

(R)-3-bromo-propane-1,2-diol

(R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

methyl N-[(4-methoxyphenyl)sulfonyl]-S-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-D-penicillamine