acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester

Base Information

• Chemical Name: acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester
• CAS No.: 924300-53-8
• Molecular Formula: C₂₂H₂₀O₈
• Molecular Weight: 412.396
• Mol file: 924300-53-8.mol

Synonyms:acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester

Chemical Property of acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester

There total 5 articles about acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione (82218-06-2) + acetic acid 4-chlorocarbonyl-2,6-dimethyl-phenyl ester (105578-34-5) → acetic acid 4-(6,8-dimethoxy-1-oxo-1H-isochromen-3-yl)-2,6-dimethyl-phenyl ester (924300-54-9) + acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester (924300-53-8)

Guidance literature:

With triethylamine; N,N,N',N'-tetramethylguanidine; In acetonitrile; at 0 - 20 ℃; for 20h; Heating / reflux;

Reference yield:

(2-formyl-3,5-dimethoxy-phenyl)-acetic acid methyl ester (602278-05-7) → acetic acid 4-(6,8-dimethoxy-1-oxo-1H-isochromen-3-yl)-2,6-dimethyl-phenyl ester (924300-54-9) + acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester (924300-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: dihydrogen peroxide; sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile / 4 h / 0 - 20 °C

2: sodium hydroxide; water / methanol / 3 h / 20 °C

3: acetic anhydride / toluene / 2 h / Reflux

4: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

With sodium chlorite; sodium dihydrogenphosphate; water; dihydrogen peroxide; acetic anhydride; triethylamine; sodium hydroxide; N,N,N',N'-tetramethylguanidine; In methanol; water; toluene; acetonitrile;

Reference yield:

2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoic acid (83375-20-6) → acetic acid 4-(6,8-dimethoxy-1-oxo-1H-isochromen-3-yl)-2,6-dimethyl-phenyl ester (924300-54-9) + acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester (924300-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol / 3 h / 20 °C

2: acetic anhydride / toluene / 2 h / Reflux

3: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

With water; acetic anhydride; triethylamine; sodium hydroxide; N,N,N',N'-tetramethylguanidine; In methanol; toluene; acetonitrile;

upstream raw materials:

6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione

acetic acid 4-chlorocarbonyl-2,6-dimethyl-phenyl ester

(2-formyl-3,5-dimethoxy-phenyl)-acetic acid methyl ester

2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoic acid

Downstream raw materials:

3-(4-hydroxy-3,5-dimethyl-phenyl)-6,8-dimethoxy-isochromen-1-one