83375-20-6

Upstream product

• 6110-30-1 methyl <3,5-dihydroxy-2-(methoxycarbonyl)phenyl>acetate 
• 6512-32-9 methyl 2-(3,5-dimethoxyphenyl)acetate 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 4670-10-4 (3,5-dimethoxyphenyl)acetic acid 
• 6512-26-1 methyl 2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoate 
• 100118-53-4 methyl 2-hydroxy-4-methoxy-6-(methoxycarbonylmethyl)benzoate 
• 602278-05-7 (2-formyl-3,5-dimethoxy-phenyl)-acetic acid methyl ester 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 616-38-6 carbonic acid dimethyl ester 
• 67-56-1 methanol 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 

Downstream Products

• 83375-23-9 2,4-Dimethoxy-6-(7-methoxy-5-methyl-4-oxo-4H-chromen-2-ylmethyl)-benzoic acid 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 
• 924300-57-2 3-[3,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one 
• 924300-56-1 3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one 
• 924300-54-9 acetic acid 4-(6,8-dimethoxy-1-oxo-1H-isochromen-3-yl)-2,6-dimethyl-phenyl ester 
• 924300-53-8 acetic acid 4-(6,8-dimethoxy-1,3-dioxo-isochroman-4-carbonyl)-2,6-dimethyl-phenyl ester 
• 1044872-19-6 3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one 
• 1044871-80-8 3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one 
• 924300-55-0 3-(4-hydroxy-3,5-dimethyl-phenyl)-6,8-dimethoxy-isochromen-1-one 
• 19314-92-2 3,4-dihydro-6,8-dihydroxy-3-methylisochromen-1-one 
• 6803-02-7 6-methoxymellein 

Relevant academic research and scientific papers

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of cancer, including NUT midline carcinoma, Burkitt's Lymphoma, Acute Myelogenous Leukemia, and Multiple Myeloma; autoimmune or inflammatory diseases or conditions, and sepsis.

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF COMPLEX DISEASES AND THEIR DELIVERY BY INSERTABLE MEDICAL DEVICES

The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.

Total Synthesis of Premithramycinone H and Related Anthrapyran Antibiotics

Two approaches are described for the preparation of 2-(1',3'-dioxoalkyl)-substituted 1-hydroxyanthraquinones 10a-d and 20a-c, which were cyclized in a biomimetic-type reaction to the anthra[1,2-b]pyran skeletons 11a-d and 21a-c of the heydamcin- or pluram

An efficient synthesis of 3,5-dimethoxyhomophthalic acid, a key intermediate for synthesis of natural isocoumarins

3,5-Dimethoxyhomophthalic acid was prepared efficiently in three steps, from 3,5-dimethoxybenzyl bromide via rhodium-catalyzed direct carbonylation to 3,5-dimethoxyphenylacetic acid followed by successive o-formylation and oxidation. Isocoumarins related

Biosyntheses of Antibiotic A26771B by Penicillium turbatum and Dehydrocurvularin by Alternaria cinerariae: Comparison of Stereochemistry of Polyketide and Fatty Acid Enoyl Thiol Ester Reductases

The biosyntheses of reduced polyketides and fatty acids were compared by use of stable isotope labeling and NMR spectroscopy.Incorporations of sodium -, -, -, -, -, and acetates i

Synthesis of Chlorinated Isocoumarin Derivatives

Syhtheses of 5-chloro-, 7-chloro-, and 5,7-dichloro-isocoumarin derivatives, including the fungal metabolites 5-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (3), 7-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (2), and 5,7-dichl