(2-Phenyl-1,3-thiazol-4-yl)methylamine

Base Information

• Chemical Name: (2-Phenyl-1,3-thiazol-4-yl)methylamine
• CAS No.: 165736-03-8
• Molecular Formula: C10H10 N2 S
• Molecular Weight: 190.269
• Hs Code.: 2934100090
• European Community (EC) Number: 640-729-7
• DSSTox Substance ID: DTXSID70353055
• Wikidata: Q72498934
• Mol file: 165736-03-8.mol

Synonyms:165736-03-8;(2-phenyl-1,3-thiazol-4-yl)methylamine;(2-Phenylthiazol-4-yl)methanamine;(2-phenyl-1,3-thiazol-4-yl)methanamine;4-Thiazolemethanamine, 2-phenyl-;1-(2-phenyl-1,3-thiazol-4-yl)methanamine;MFCD02682055;C-(2-phenyl-thiazol-4-yl)-methylamine;Enamine_005991;Oprea1_835986;SCHEMBL590109;DTXSID70353055;2-phenyl-4-(aminomethyl)thiazole;PMFCMLGAPHZRTE-UHFFFAOYSA-N;(2-phenylthiazol-4-yl)methylamine;HMS1411E01;BBL029750;STK350773;AKOS000122123;SDCCGMLS-0066003.P001;MS-22150;BB 0259499;FT-0604648;EN300-57445;W-205948

Chemical Property of (2-Phenyl-1,3-thiazol-4-yl)methylamine

Chemical Property:

• Vapor Pressure: 3.65E-05mmHg at 25°C
• Boiling Point: 353.2°Cat760mmHg
• Flash Point: 167.4°C
• PSA: 67.15000
• Density: 1.208g/cm³
• LogP: 2.96910
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.05646950
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

98%min ^*data from raw suppliers

(2-Phenyl-1,3-thiazol-4-yl)methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CS2)CN

Technology Process of (2-Phenyl-1,3-thiazol-4-yl)methylamine

There total 9 articles about (2-Phenyl-1,3-thiazol-4-yl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-4-chloromethylthiazole (4771-31-7) → (2-phenylthiazol-4-yl)methanamine (165736-03-8)

Guidance literature:

With ethanol; ammonia;

Reference yield:

N-(2-phenyl-thiazol-4-ylmethyl)-phthalimide → (2-phenylthiazol-4-yl)methanamine (165736-03-8)

Guidance literature:

With hydrogenchloride;

Reference yield:

benzenecarbothioamide (2227-79-4) → (2-phenylthiazol-4-yl)methanamine (165736-03-8)

Guidance literature:

Multi-step reaction with 3 steps

3: aqueous HCl

With hydrogenchloride;

upstream raw materials:

2-phenyl-4-chloromethylthiazole

benzenecarbothioamide

benzoic acid

2-phenylthiazole-4-carboxylic acid ethyl ester

Refernces

• 1、 Dang, Mingming,Liu, Minhua,Huang, Lu,Ou, Xiaoming,Long, Chuyun,Liu, Xingping,Ren, Yeguo,Zhang, Ping,Huang, Mingzhi,Liu, Aiping. "Design, synthesis, and bioactivities of novel pyridazinone derivatives containing 2-phenylthiazole or oxazole skeletons". . p. 4088 - 4098. Retrieved 2020/10/02.
• 2、 Yan, Zhongzhong,Liu, Aiping,Ou, Yingcan,Li, Jianming,Yi,Zhang, Ning,Liu, Minhua,Huang, Lu,Ren, Jianwei,Liu, Weidong,Hu, Aixi. "Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety". . p. 3218 - 3228. Retrieved 2019/06/05.