4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine

Base Information

Chemical Name:4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine
CAS No.:132938-37-5
Molecular Formula:C₈H₈ClN₃
Molecular Weight:181.625
Hs Code.:
DSSTox Substance ID:DTXSID80697139
Wikidata:Q72454734
Mol file:132938-37-5.mol

Synonyms:132938-37-5;4-CHLORO-6-METHYL-5-(2-PROPYNYL)-2-PYRIMIDINAMINE;4-chloro-6-methyl-5-prop-2-ynylpyrimidin-2-amine;2-Pyrimidinamine, 4-chloro-6-methyl-5-(2-propyn-1-yl)-;4-CHLORO-6-METHYL-5-(PROP-2-YN-1-YL)PYRIMIDIN-2-AMINE;DTXSID80697139;AMY25973;AKOS006237151

Suppliers and Price of 4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLORO-6-METHYL-5-(2-PROPYNYL)-2-PYRIMIDINAMINE 95.00%
5MG
$ 502.99

Total 7 raw suppliers

Chemical Property of 4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine

Chemical Property:

Refractive Index:1.61
Boiling Point:349.3 °C at 760 mmHg
Flash Point:165 °C
PSA：51.80000
Density:1.302 g/cm³
LogP:1.77750
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:181.0406750
Heavy Atom Count:12
Complexity:198

Purity/Quality:

98%min ^*data from raw suppliers

4-CHLORO-6-METHYL-5-(2-PROPYNYL)-2-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC(=N1)N)Cl)CC#C

Technology Process of 4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine

There total 2 articles about 4-Chloro-6-methyl-5-(2-propynyl)-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 81887-01-6
2-Amino-6-methyl-5-(2-propynyl)-4(1H)-pyrimidinone

: 132938-37-5
2-Amino-4-chloro-6-methyl-5-(2-propynyl)pyrimidine

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; 1) reflux, 7 h, 2) RT;
DOI:10.1021/jo00007a026

Reference yield:

: 36600-70-1,123325-96-2
ethyl 2-acetylpent-4-ynoate

: 132938-37-5
2-Amino-4-chloro-6-methyl-5-(2-propynyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / methanol / 15 h / Heating

2: 23 percent / POCl₃ / dimethylformamide / 1) reflux, 7 h, 2) RT

With trichlorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00007a026