2-(2-Pyridyl)-4-trifluoromethylimidazole

Base Information

• Chemical Name: 2-(2-Pyridyl)-4-trifluoromethylimidazole
• CAS No.: 33468-85-8
• Molecular Formula: C₉H₆F₃N₃
• Molecular Weight: 213.162
• Hs Code.: 2933990090
• Mol file: 33468-85-8.mol

Synonyms:Pyridine,2-[4-(trifluoromethyl)-1H-imidazol-2-yl]- (9CI);Pyridine,2-[4-(trifluoromethyl)imidazol-2-yl]- (8CI);2-(2-Pyridyl)-4(5)-trifluoromethylimidazole;

Chemical Property of 2-(2-Pyridyl)-4-trifluoromethylimidazole

Chemical Property:

• Vapor Pressure: 2.54E-05mmHg at 25°C
• Melting Point: 160-161 °C
• Refractive Index: 1.519
• Boiling Point: 369.3 °C at 760 mmHg
• Flash Point: 177.2 °C
• PSA: 41.57000
• Density: 1.393 g/cm³
• LogP: 2.49050

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2-PYRIDYL)-4-TRIFLUOROMETHYLIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Pyridyl)-4-trifluoromethylimidazole

There total 3 articles about 2-(2-Pyridyl)-4-trifluoromethylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

pyridine-2-carbaldehyde (1121-60-4) + 1,1-dibromo-3,3,3-trifluoroacetone (431-67-4) → 2-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridine (33468-85-8)

Guidance literature:

1,1-dibromo-3,3,3-trifluoroacetone; With sodium acetate; for 0.5h; Heating;

pyridine-2-carbaldehyde; With ammonium hydroxide; In methanol; at 20 ℃; for 20h;

DOI:10.1021/jm991154w

Reference yield:

→ 2-(4-trifluoromethyl-1(3)H-imidazol-2-yl)-pyridine (33468-85-8)

Guidance literature:

1,1,1.Trifluoro-3,3-dibrom-aceton, wss. Na-Acetat, Δ, entspr. Aldehyd in Me. u. konz. NH4OH (bei 20grad);

DOI:10.1021/jm00243a007

Reference yield:

→ 2-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridine (33468-85-8)

Guidance literature:

Pyridin-2-aldehyd, Dibromtrifluoraceton;

upstream raw materials:

pyridine-2-carbaldehyde

1,1-dibromo-3,3,3-trifluoroacetone

Downstream raw materials:

2-(2-pyridyl)-1H-4-imidazolcarbaldehyde

2-(2-pyridyl)-4-cyano-1H-imidazole

Refernces

• 1、 Dhainaut, Alain,Tizot, André,Raimbaud, Eric,Lockhart, Brian,Lestage, Pierre,Goldstein, Solo. "Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones". . p. 2165 - 2175. Retrieved 2007/10/03.
• 2、 -. "2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation". . . Retrieved 2008/06/13.